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Exp Clin Endocrinol Diabetes 1988; 91(3): 350-354
DOI: 10.1055/s-0029-1210768
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Endogenous Opiates Do Not Influence Glucose and Lipid Metabolism in Rat Adipocytes

H. Hauner, G. Glatting, H. H. Ditschuneit* , E. F. Pfeiffer
  • Department of Internal Medicine I (Chairman: Prof. Dr. med. Dr. h.c. mult. E. F. Pfeiffer), FRG
  • * Department of Internal Medicine II (Chairman: Prof. Dr. H. Ditschuneit), Medizinische Klinik und Poliklinik der Universität Ulm, FRG
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Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

The effects of the opiates β-endorphin, dynorphin, met-enkephalin, leu-enkephalin, morphine and of the opiate-antagonist naloxone on glucose metabolism and lipolysis were studied in isolated rat adipocytes. None of the tested substances was found to alter 125I-Insulin binding. The opiates did not influence 2-deoxy-glucose uptake or glucose incorporation into lipids. They also did not exhibit a lipolytic activity.

We conclude that the disturbances of glucose homeostasis induced by endogenous opiates are not mediated by an effect on peripheral glucose metabolism.

Key words

Endogenous opiates - Glucose metabolism - Rat adipose tissue