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Exp Clin Endocrinol Diabetes 1988; 92(4): 43-50
DOI: 10.1055/s-0029-1210780
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Insulin and Release of Neurohypophysial Hormones: In Vivo and In Vitro Studies1)

J. W. Guzek, Aleksandra Lewandowska, Bozena Stempniak
  • Department of Pathophysiology (Head: Prof. Dr. J. W. Guzek) University School of Medicine, Łód'ź/Poland
1) This work was supported by the Polish Academy of Sciences (project CPBP 06.03). Presented at the Second World Congress of Neuroscience, Budapest, 16—21. 08. 1987 (abstract No 406).
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Publikationsverlauf

1987

Publikationsdatum:
16. Juli 2009 (online)

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Summary

No significant effect of intracerebroventricular administration of insulin on the bioassayed neurohypophysial storage of vasopressin and oxytocin could be found. This finding, however, only indirectly reflects possible changes of vasopressin and oxytocin release.

Incubation of neurointermediate lobes in Locke's solution containing 3.3 μmol/l insulin resulted in an inhibition of oxytocin release under resting conditions as well as in a decrease of both vasopressin and oxytocin release during depolarization due to excess potassium. These results seem to suggest a possible regulatory role of brain insulin in the mechanisms of release of neurohypophysial hormones.

Key words

Insulin - Vasopressin - Oxytocin - Neurohypophysis