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Exp Clin Endocrinol Diabetes 1988; 92(5): 154-160
DOI: 10.1055/s-0029-1210795
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Glycogen Phosphorylase Activation by Progesterone in Liver

M. J. Sancho, A. Gomez-Muñoz, A. Sanchez-Bueno, M. Trueba, A. Marino
  • Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad del País Vasco, Bilbao/Spain
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Glycogen phosphorylase activity is increased before protein synthesis activation by progesterone. This effect is not blocked by antibiotics (actinomycin D and cycloheximide) that are mown to inhibit mRNA or protein synthesis. At times similar to those of phosphorylase activation, 3AMP are not enhanced, as would be expected considering the classical glycogenolytic cascade, but depleted with respect to control values. A little earlier, cGMP levels are significantly increased.

Key words

Progesterone - Glycogen phosphorylase - cAMP - cGMP - Chicken liver