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Exp Clin Endocrinol Diabetes 1989; 93(2/03): 187-192
DOI: 10.1055/s-0029-1210855
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of Serum from Diabetes-Prone BB/OK Rats on Neonatal Rat Pancreatic Islets and Islet Cell Suspensions

D. Schröder, B. Hehmke, Ingrid Klöting, W. Besch
  • Central Institute of Diabetes (Head: OMR Prof. Dr. H. Bibergeil) Karlsburg, GDR
Further Information

Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Humoral-mediated cytolytic activity against neonatal rat pancreatic islet cells as well as islets of Langerhans was detected in sera of newly diagnosed diabetic BB/OK rats by measurement of enhanced 51Cr-release or insulin leakage. Beta-cell-specific functions of islet cell suspensions such as insulin secretion and (pro)insulin biosynthesis can be affected by BB rat serum in vitro.

Key Words

BB rat serum - Islet cell cytotoxicity - Insulin leakage - (Pro)insulin biosynthesis