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Exp Clin Endocrinol Diabetes 1989; 93(2/03): 248-254
DOI: 10.1055/s-0029-1210864
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Pancreatic Islets Obtained from Pancreases with Short-term Exocrine Atrophy - Disturbed Morphology but Normal in Vitro Response to Various Stimuli

J. Bodziony* , P. O. Schwille
  • Department of Biochemistry and IV Clinic of General Surgery, Silesian Medical Academy, Katowice, Poland; Division of Experimental Surgery, Department of Surgery, University of Erlangen, FRG
* Supported by the Alexander von Humboldt Foundation, Bonn, FRG.
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

The morphology and function of islets isolated from rat pancreases with short-term (16 days) exocrine atrophy was investigated. It was found that this type of atrophy induced changes in the shape and morphological structure of pancreatic islets. However, the function of isolated islets did not change, as investigated by the basal or glucose-stimulated secretion of insulin, glucagon and somatostatin, and by the CCK-stimulated secretion of insulin. We conclude that the rat pancreas brought to atrophy by a short-term ligation of the pancreatic duct can be considered as a rich source of functionally viable islets.

Key Words

Atrophy of the exocrine pancreas - Isolated islets - Islet morphology - Secretion of hormones