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DOI: 10.1055/s-0029-1210871
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Influence of Trivalent Chromium on the Beta-Cell Function
Publikationsverlauf
1988
Publikationsdatum:
16. Juli 2009 (online)
![](https://www.thieme-connect.de/media/eced/19890203/lookinside/thumbnails/10.1055-s-0029-1210871-1.jpg)
Summary
Application of trivalent chromium (daily 1 mg, p.o.) to pregnant rats in the time of gestation and thereafter — beginning with the first day of the gestation and lasting for 50 days — did not change the i.p. glucose tolerance of the adult animals.
The insulin concentration in serum 30 min after glucose loading was decreased significantly. The basal concentration of serum insulin of neonates was diminished, too.
The insulin content of the whole pancreas was decreased in mother animals and increased in neonates.
Secretion of insulin by isolated islets of the neonatal animals was unchanged.
Insulin biosynthesis of the islets of these animals was increased in presence of 6 and 15 mM glucose, respectively. These data suggest an effect of trivalent chromium on endocrine pancreas.
Key Words
Trivalent chromium - Endocrine pancreas - Secretion - Biosynthesis of insulin - Rat