RSS-Feed abonnieren
DOI: 10.1055/s-0029-1210874
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Glucoregulatory Function of Thyroid Hormones: Evidence for an Insulin-Independent Effect
Publikationsverlauf
1988
Publikationsdatum:
16. Juli 2009 (online)
Summary
The effect of hyperglycemia on glucose kinetics was investigated in normal and T4-treated miniature pigs. 1. T4-treatment increased basal plasma glucose (G) (+20%) and glucose turnover (+36%). 2. Glucose infusion (2 mg/kg × min) in controls increased insulin and glucose utilization (Rd), but decreased glucagon and hepatic glucose production (Ra). After T4-treatment glucose increased insulin, decreased glucagon and Ra but only a slight effect on G and Rd were observed. 3. Infusing glucose + somatostatin resulted in hyperglycemia in both groups due to an initial fall in Ra and Rd followed by an increase in Rd, where total Ra (endogenous + exogenous exceeded Rd. Glucose intolerance was more pronounced in controls, due to a T4-induced increase in Rd. During this non-steady state the increment in Rd per increment in G was calculated and showed 1.5 in controls and 2.5 after T4-treatment. These data give evidence that thyroid hormones increase glucose utilization during hypoinsulinemia.
Key Words
Hyperthyroidism - Glucose production - Glucose utilization