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Exp Clin Endocrinol Diabetes 1990; 95(1): 105-109
DOI: 10.1055/s-0029-1210941
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Circulating Levels of Placental Protein 12 (PP 12) in Diabetic Pregnancy Complicated by Retinopathy*)

V. Briese1 , G. N. Than2 , D. G. Szabo3 , A. Szilagyi2 , R.-R. Strache4 , P. Heinke1 , H. Hopp1 , H.-H. Büttner4
  • 1Central Institute of Diabetes “Gerhardt Katsch” (Director : OMR Prof. Dr. sc. med. H.Bibergeil), Karlsburg/GDR
  • 2Obstetrics and Gynecological Clinic (Director : Prof. Dr. sc. med. I. Csaba), University Medical School, Pecs/Hungary
  • 3Institute of Biochemistry (Director : Prof. Dr. sc. med. H. Alkonyi), Pecs/Hungary
  • 4Obstetrics and Gynecological Clinic (Director : Prof. Dr. sc. med. H. H. Büttner), Wismar/GDR
*) Dedicated to Prof. H. Bibergeil on the occasion of his 65th birtday.
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

Placental protein 12 (PP 12) is a soluble tissue antigen. Immunohistochemical studies have localized PP 12 in the placental syncytiotrophoblast, chorion and amnion, and also in the decidua. During normal pregnancy serum-PP 12 is already raised in the first trimester, there is then a peak at 18 weeks, a gradual fall until 32 weeks, and a moderate increase thereafter.

The mean of the healthy control group at 18 weeks of pregnancy was 122.9 ± 47.5 μg/l. The mean of the diabetic group with retinopathy at the same time was 192.2 ± 78.8 μg/l. There was no significant difference between background retinopathy and the proliferative form of diabetic retinopathy. At all times during pregnancy the median values of PP 12 in diabetic pregnancies were significantly (p < 0.01) above the control values. Increased PP 12 levels in diabetic pregnancy complicated by retinopathy are probably caused by decidual, placental and amniotic leakages.

Key words

Placental protein 12 (PP 12) - PP 12 serum levels in high risk pregnancies - PP 12 in diabetic retinopathy