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Exp Clin Endocrinol Diabetes 1990; 95(3): 331-338
DOI: 10.1055/s-0029-1210973
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Serum Aldosterone Response to Metoclopramide in Normal Subjects and Acromegalic Patients

S. Zacharieva, I. Stoeva, P. Matrozov, K. Andonova
  • Institute of Endocrinology and Gerontology (Director : Ass. Prof. Dr. Sc. Med. D. Koev), Medical Academy, Sofia/Bulgaria
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1989

Publikationsdatum:
16. Juli 2009 (online)

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Summary

The acute effects of metoclopramide on aldosterone and prolactin levels were studied in 11 normal subjects, 8 normotensive and 8 hypertensive acromegalics. Metoclopramide (10 mg i.v.) induced a similar serum aldosterone increase in normal subjects and normotensive acromegalics. Hypertensive acromegalics showed elevated basal serum aldosterone level and blunted aldosterone response to metoclopramide. The prolactin response te metoclopramide was blunted in acromegalics in comparison with normal subjects but the difference was statistically significant only in hypertensive patients. The blunted aldosterone and prolactin responses to metoclopramide in hypertensive acromegalics suggest that there is a dopamine deficiency at central and adrenal level in these patients.

Key words

Aldosterone - Prolactin - Metoclopramide - Acromegaly