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Exp Clin Endocrinol Diabetes 1990; 96(5): 207-212
DOI: 10.1055/s-0029-1211011
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Kidney Damage in Rats Bearing an Adrenocorticotropin and Prolactin Secreting Tumor

Davorka Dobrović-Jenik, Štefica Dušanek, S. Milković
  • Laboratory of Pharmacology (Prof. Dr. St. Milković), Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb/Yugoslavia
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

The effect of chronic high plasma corticosteroids' concentration upon renal function was studied in rats bearing a transplantable pituitary mammotropic tumor which produces large quantities of ACTH and prolactin (MtTF4S). Kidney splanchnomegaly and degenerative changes of renal cortex, particularly in proximal tubules, as well as cytolysis and appearance of vacuoles were noticed in tumor bearing rats. (Na+ + K+)-ATPase activity in renal plasma membranes decreased 67% in rats with a tumor secreting ACTH and prolactin, and 64% in rats with a tumor secreting growth hormone and prolactin when compared with controls. After adrenalectomy of MtTF4S rats, kidney weight as well as plasma concentrations of urea, sodium, chloride and phosphate ions were normalized indicating the involvement of adrenal glands in the development of disturbances in renal function.

Key words

Pituitary tumor - Corticosteroids - Kidney - ACTH - Prolactin