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Exp Clin Endocrinol Diabetes 1991; 97(1): 34-38
DOI: 10.1055/s-0029-1211035
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Neurotensin Inhibits the Stimulatory Effect of Angiotensin-II and Potassium on Aldosterone Secretion by Rat Zona Glomerulosa Cells

G. Mazzocchi, L. K. Malendowicz, P. G. Andreis, G. G. Nussdorfer
  • Department of Anatomy, University of Padua/Italy; Department of Histology and Embryology, Poznan Academy of Medicine/Poland
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Publication History

1990

Publication Date:
16 July 2009 (online)

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Summary

Neurotensin (NT), a hypothalamic peptide which is also contained in the chromaffin granules of adrenal medullary cells, did not affect either basal or ACTH-stimulated secretory activity of isolated rat zona glomerulosa (ZG) cells. Conversely, NT was found to exert a strong dose-dependent inhibitory effect on aldosterone response of ZG cells to their two main calcium-dependent secretagogues angiotensin-II and potassium. These findings suggest that NT may interfere with the angiotensin-II- or potassium-induced activation of protein kinase C, possibly by blunting the rise in the cytosolic calcium concentration.

Key words

Neurotensin - Zona glomerulosa - Aldosterone - Protein kinase C - Rat