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Exp Clin Endocrinol Diabetes 1991; 97(1): 91-96
DOI: 10.1055/s-0029-1211044
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

A Study of Human Calcitonin in an Ovarian Carcinoid and Ovarian Cancers

Harutake Sakura, Toshiro Fujii, Kazuya Okamoto
  • Department of Obstetrics and Gynecology, and Pathology, Hamamatsu Medical Center, Hamamatsu/Japan
Further Information

Publication History

1990

Publication Date:
16 July 2009 (online)

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Summary

High concentration of human calcitonin (hCT) was found in an ovarian carcinoid by radioimmunoassay. The hCT value was not affected by the presence of protease inhibitors. To confirm the presence of hCT in an ovarian carcinoid, hCT was isolated by the Baghdiantz method. The molecular weight of the ovarian hCT was determined using Sephadex G-75 gel filtration. Though the molecular weight of the ovarian hCT was variable, 90% corresponded to that of the authentic hCT. The carcinoid cells were examined by immunoperoxidase techniques. Those composed of strumal and travecular structure were all argyrophilic, but hCT was only found in strumal structure. Significant concentrations of hCT were also found in ovarian cancers.

Key words

Calcitonin - Ovarian carcinoid - Ovarian cancer