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Exp Clin Endocrinol Diabetes 1991; 98(4): 15-22
DOI: 10.1055/s-0029-1211095
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Different Secretory Response of Pancreatic Isolated Lobules and Dissociated Acini from Hypothyroid Rats to Exogen TRH

A. Blanco-Molina, F. Lopez Segura, E. Vara* , J. Lopez Miranda, J. Torre-Cisneros, F. Perez-Jimenez
  • Department of Internal Medicine (Head: Dr. J. Jiménez-Péreperez), Reina Sofia Hospital, S. A. S. (Head: Dr. G. Pérez), Medical School, University of Córdoba, Madrid/Spain
  • * Department of Biochemistry (Head: J. Tamarit-Rodriguez), Medical School, University of Madrid, Madrid/Spain
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Publication History

1990

Publication Date:
16 July 2009 (online)

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Summary

This paper analyses the effect of hypothyroidism on pancreatic TRH and somatostatin concentrations, as well as the action of exogen TRH on pancreatic arrrylase secretion from isolated lobules and dissociated acini of both healthy and hypothyroid rats. In the hypothyroid group, pancreatic TRH and somatostatin increased. In the pancreatic lobules of untreated animals, bethanechol produced stimulatory action that was inhibited by TRH. On the other hand, lobules from hypothyroid rats did not respond to bethanechol stimulation. Acini amylase secretion after bethanechol stimulation was similar in both groups, although hypothyroid animals were more sensitive to the inhibitory effect of TRH. These findings suggest the existence of a factor blocking the amylase secretion in pancreatic lobules. This agent, probably TRH, could be eliminated in the experimental model of dissociated acini.

Key words

TRH - Hypothyroid rat - Amylase secretion - Isolated lobules - Dissociated acini