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Exp Clin Endocrinol Diabetes 1992; 99(2): 113-115
DOI: 10.1055/s-0029-1211149
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Naloxone Stimulation Test in Women with Hypothalamic Amenorrhea: a Preliminary Report

B. Krause, Silke Möller, G. Göretzlehner, U. Ulrich, F. Matuszewski, W. Wodrig, A. Weber
  • Clinic for Gynecology and Obstetrics, and Clinic for Radiology, Ernst Moritz Arndt University, Greifswald/Germany
Further Information

Publication History

1991

Publication Date:
15 July 2009 (online)

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Summary

We researched the possibility of the induction of ovulation by means of chronic opioid receptor blockade in 4 women with hypothalamic amenorrhea. Daily 4 mg naloxone were given as a bolus injection intravenously. By means of continuous determination of LH, FSH, 17-ß-estradiol (E2) and progesterone as well as of sonographic fol liculometry follicular growth and subsequent ovulation should have been proved. Neither we found alterations of the basal values of LH, FSH, E2 and progesterone, nor we observed a follicular growth. These results lead us to the conclusion to put a naloxone stimulation test before further therapy. In this way opioid mediated hypothalamic ovarian insufficiencies can be registered and a therapy optimum can be reached early.

Key words

Hypothalamic amenorrhea - Opioid receptor blockade - Ovulation induction - Naloxone stimulation test