PDF herunterladen
Exp Clin Endocrinol Diabetes 1993; 101(3): 178-182
DOI: 10.1055/s-0029-1211227
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Relationship between the Monoamine and Gonadotropin Content in Follicular Fluid of Preovulatory Graafian Follicles after Superovulation Treatment*

J. Bódis, G. Hartmann1 , A. Török2 , Z. Bognár, H.-R. Tinneberg2 , P. Cledon2 , V. Hanf2
  • 1Department of Obstetrics and Gynecology (Head: Prof. J. Székely), Institute of Physiology (Head: Prof. L. Lénárt), University Medical School of Pécs/Hungary
  • 2Department of Obstetrics and Gynecology (Head: Prof. H. A. Hirsch), University Medical School of Tübingen/ Germany
* J. Bódis was generously supported by the Alexander von Humboldt Foundation (AvH).
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
15. Juli 2009 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

Noradrenaline (NA), serotonin (5HT), dopamine (DA), FSH, LH and prolactin (PRL) content was determined in 104 preovulatory follicular fluids obtained from 44 patients undergoing in vitro fertilization. The patients were given human menopausal gonadotropin (HMG) for ovarium stimulation, ovulation was induced with 10000 IU human chorionic gonadotropin (HCG) 34 — 36 hours prior to the follicular aspiration by vaginal ultrasound. Classification of the oocytes was performed by direct microscopic evaluation differentiating three groups of oocytes: Group I.: prophase I; Group II.: meta-phasel; Group III.: metaphase II. There was no significant difference in monoamine and FSH content of follicular fluid at different stage of the oocyte maturation. LH and PRL significantly increased parallel with oocyte maturation (38.9; 48.8; 56.7 IU/1 and 1324; 2382; 3134 IU/1). significant negative correlation was observed in Group I. between 5HT-LH (r = -0.64); in Group II. between NA-LH (r = - 0.62) and NA-PRL (r = -0.51). Significant positive correlation were found in Group I. between FSH-LH (r = 0.63), in Group II. between LH-PRL (r = 0.56), in Group III. between NA-5HT (r = 0.66), NA-DA (r = 0.80) and 5HT-DA (r = 0.66). These observations suggest that action of LH and PRL may be negatively modulated by 5HT and NA in the final stage of oocyte maturation.

Key words

Monoamines - Gonadotropins - Oocyte maturation