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Exp Clin Endocrinol Diabetes 1993; 101(6): 371-373
DOI: 10.1055/s-0029-1211260
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Atrial Natriuretic Peptide-Like Immunoreactive Material (ANP-LI) is Released from the Adrenal Gland by Splanchnic Nerve Stimulation

L. Duntas, S. R. Bornstein, W. A. Scherbaum* , J. J. Holst**
  • Department of Internal Medicine I, University of Ulm, Germany
  • * Department of Internal Medicine III, University of Leipzig, Germany
  • ** Department of Medical Physiology C, The Panum Institute, University of Copenhagen, Denmark
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

We investigated the release of atrial natriuretic peptide-like immunoreactive material (ANP-LI) after splanchnic nerve stimulation of isolated perfused adrenal glands. Electrical stimulation of the splanchnic nerves caused a statistically significant increase of ANP-LI (186 ± 12 pg • min ; p < 0.05) at 5 min. after stimulation. The integrated ANP-LI release after stimulation was amounted to 354 ± 6.8% over basal. The regulation of ANP through the sympathoadrenal system may indicate an important role of ANP in adrenal steroidogenesis.

Key words

ANP-LI - Adrenal gland - Splanchnic nerve stimulation