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Exp Clin Endocrinol Diabetes 1995; 103: 46-55
DOI: 10.1055/s-0029-1211394
Molecular Biology of Islets of Langerhans

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Gene Therapy of Diabetes Mellitus — Aims, Methods and Future Prospects

M. Tiedge, S. Lenzen
  • Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
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Publikationsdatum:
15. Juli 2009 (online)

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Summary

Progress in pancreatic islet research and molecular biology techniques has opened the perspective for gene therapy of diabetes mellitus. This review will focus on the prerequisites for the generation of genetic ally engineered insulin-producing cells and current methods of gene transfer. A short account of the genetically modified insulin-secreting cell lines generated so far also given. Although still experimental each of these new insulin-secreting cell lines is a step forward on the way to gene therapy of human diabetes.

Key words

Gene therapy - Pancreatic B-cell - Diabetes mellitus - Viral vectors - Glucokinase - GLUT2