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Exp Clin Endocrinol Diabetes 1995; 103: 71-73
DOI: 10.1055/s-0029-1211397
DOI: 10.1055/s-0029-1211397
Molecular Biology of Islets of Langerhans
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Overexpression of Calcium/Calmodulin-Dependent Protein Kinase II in Insulinoma Cells by use of a Retroviral Vector
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Publikationsverlauf
Publikationsdatum:
15. Juli 2009 (online)
Summary
The manner in which increasing intracellular calcium levels lead to insulin exocytosis is not known. Possibly the signal is mediated by activation of calcium/ calmodulin-dependent protein kinase II (CaM Kin II). In this work the establishment of an insulinoma cell line stably overexpressing CaM Kinase II subtype delta 2 by an ecotropic retroviral transduction system is described.
Key words
Calmodulin dependent protein kinases - antibody - retrovirus - transfection