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Exp Clin Endocrinol Diabetes 1996; 104(5): 392-395
DOI: 10.1055/s-0029-1211473
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Urinary cGMP excretion after hormone replacement therapy in postmenopausal women

A. O. Mueck1 , H. Seeger1 , S. Kaßpohl-Butz2 , A. T. Teichmann2 , T. H. Lippert1
  • 1Section of Clinical Pharmacology, Department of Obstetrics & Gynecology, University of Tübingen, Germany
  • 2Department of Obstetrics & Gynecology, Clinic Aschaffenburg, Germany
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

It is well established that estrogens and progestogens are able to influence the vasotonus in postmenopausal women. The present study was undertaken to find out if the NO/cGMP-system is involved in this hormone action. Urinary cGMP excretion which can reflect intracellular cGMP production elicited by NO (EDRF) was investigated in 20 postmenopausal women. In an open cross-over study design norethisterone acetate was administered orally for 8 days, estradiol valerate orally for 9 days and a combination of both substances for 12 days. After all three treatment phases urinary cGMP expressed as percentage of the pretreatment value was increased at a statistically significant level. Due to high individual variations no significant differences could be found among the values after the three treatment phases. It was concluded that the NO/cGMP-system may play a role in maintaining vasotonus in postmenopausal women under hormone replacement therapy.

Key words

Postmenopausal women - hormone replacement therapy - urinary cGMP excretion