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Exp Clin Endocrinol Diabetes 1998; 106(4): 299-302
DOI: 10.1055/s-0029-1211989
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The genomic organization of the human GLP-1 receptor gene

A. Wilmen, A. Walkenbach, P. Füller, B. Lankat-Buttgereit, R. Göke, B. Göke
  • Clinical Research Group for Gastrointestinal Endocrinology. Philipps-University of Marburg, Germany
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Publikationsdatum:
14. Juli 2009 (online)

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Summary

The genomic organization of the human gene encoding the receptor for glucagon-like peptide-1 (GLP-1 (7-37)/(7-36) amide) was analyzed to reveal the relationship to other G-proteincoupled receptors. The coding sequence of the GLP-1 receptor is interrupted by 12 introns. These introns are uniformly distributed within the open reading frame. The length of the introns varies between 6.6 kb and 100 bp, in contrast to the relative constant length of lOt) bp of the exons. All of the exon/intron splice junctions characterized followed the consensus GT-AG rule. A comparison of the genomic structure with other related receptor genes indicates that the exon/intron organization is well-conserved among the VIP! glucagon/secretin receptor family.

Key words

Glucagon-like peptide- 1 receptor - genomic organization - exon/intron boundaries