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DOI: 10.1055/s-0029-1212010
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Ganglioglioma of the neurohypophysis with secretion of vasopressin
Publication History
Publication Date:
14 July 2009 (online)
Summary
A patient with a ganglioglioma of the neurohypophysis developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present the case and describe its microscopic and ultrastructural features. Malignant neoplasms were thought to be the main cause of ectopic production of vasopressin.
Head trauma, infection, or drugs, however, can also induce hyper-secretion of vasopressin. Mechanical compression of the pituitary stalk can lead to an excessive antidiuretic hormone (ADH) release by affecting the inhibitory system. Primary neuroendocrine tumors of the hypothalamic-neurohypophyseal system are extremely rare. We demonstrate the presence of vasopressin in the tumor cells by immunocytochemistry. This represents the first case of SIADH caused by a tumor of the neurohypophysis.
Key words
Ganglioglioma - SIADH - neurohypophysis - immuno-cytochemistry - vasopressin