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Exp Clin Endocrinol Diabetes 1999; 107(3): 195-197
DOI: 10.1055/s-0029-1212097
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Finasteride treatment for one year in 35 hirsute patients

F. Bayram1 , I. I. Müderris2 , Y. Şahin2 , F. Keleştimur1
  • 1Department of Endocrinology, Erciyes University, Faculty of Medicine, Kayseri, Turkey
  • 2Department of Obstetrics and Gynecology, Erciyes University, Faculty of Medicine, Kayseri, Turkey
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Publication History

Publication Date:
14 July 2009 (online)

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Summary

This study was performed to confirm the favourable therapeutic effects of finasteride in hirsute women as described by previous publications of different research groups. Our study was a non-randomized, prospective clinical trial. Thirty five patients with hirsutism were included in the study. The patients received 5mg finasteride orally once per day over a period of 12 months. Hirsutism score, FSH, LH, E2, total T, free T, androstenedione (A), DHEAS, 17-hydroxyprogesterone (17-OHP) and sex hormone-binding globulin (SHBG) levels were determined in all the patients before treatment and every 6 months during treatment.

The modified Ferriman-Gallwey score decreased from a mean of 19.06 ± 6.12 to 11.31 ± 4.93 during the study. Clinical improvement in the degree of hirsutism was observed in 26 of 35 patients. The percent reductions in hirsutism scores (mean% ± SD) at 6 and at 12 months were 25.8 ± 11.3 and 41.3 ± 18.5, respectively. During the finasteride therapy E2 and SHBG were increased significantly while DHEAS was decreased significantly at 12 months. There were no significant changes in the values of the other hormones and no serious side effects were observed in the study.

In conclusion, finasteride is a well tolerated therapeutic agent without significant side pathological laboratory findings and can be used in the treatment of hirsutism.

Key words

Finasteride - hirsutism