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DOI: 10.1055/s-0029-1213528
© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
L-Prolin zur Behandlung von degenerativen Gelenkerkrankungen
Publikationsverlauf
Publikationsdatum:
10. Juni 2009 (online)
Zusammenfassung
L-Prolin ist bei der Biosynthese von kollagenen Geweben bedeutsam. Durch die enzymatische Umwandlung von L-Prolin wird Hydroxy-Prolin gebildet. L-Prolin und Hydroxy-Prolin stabilisieren die Fibrillen des reifen Kollagens. Kollagen ist einer der Hauptbestandteile der extrazellulären Matrix von hyalinem Knorpelgewebe. In einer klinischen Studie bei Sportlern konnte gezeigt werden, dass die Gabe von 3 g L-Prolin/Tag eine effektive Schmerztherapie ist. Erfahrungen aus der Allgemeinarztpraxis belegen den therapeutischen Effekt von L-Prolin bei reaktivierten degenerativen Gelenkerkrankungen.
Abstract
L-Proline is important in the biosynthesis of collagenic tissues. By the enzymatic transformation of L-Proline, Hydroxyproline is formed. L-Proline and Hydroxyproline stabilize the fibrils of the mature collagen. Collagen is one of the main components of the extracellular matrix of hyaline cartilaginous tissue. In a clincial study with athletes it was possible to show, that a dose of 3 g L-Proline/day is an effective pain therapy. Experience from a practice of a general practitioner proves the therapeutic effect of L-Proline in the case of degenerative joint diseases.
Schlüsselwörter
L-Prolin - degenerative Gelenkerkrankungen - Arthrose - kollagene Strukturen - hyaliner Knorpel
Keywords
L-Proline - degenerative joint diseases - arthrosis - collagenic structures - hyaline cartilage
Literatur
- 01 Adams E, Frank L. Metabolism of proline and the hydroxyprolines. Ann Rev Biochem. 1980; 49 1005-1061
- 02 Barnes M J. Function of ascorbic acid in collagen metabolism. Annals of the New York Academy of Science. 1975; 258 264-277
- 03 Bates C J. Proline and hydroxyproline excretion and vitamin C status in elderly human subjects. Clinical Science and Molecular Medicine. 1977; 52 535-543
- 04 Hiramatsu T. et al . Plasma proline and leucine kinetics: response to 4 week with praline-free diets in young adults. Am J Clin Nutr. 1994; 60 (2) 207-215
- 05 Lachin J M. Some large-sample distribution-free estimators and tests for multivariate partially incomplete data from two populations. Stat Med. 1992; 11 1151-1170
- 06 Lever M. et al . Glycine betaine and proline in human blood and urine. Biochim Biophys Acta. 1994; 1200 (3) 259-264
- 07 Lutostanska A. et al . A search for new active amino acids responsible for pharmacological activity of collagen degradation products. Pol J Pharmacol. 1993; 45 253-268
- 08 Martinek V. Anatomie und Pathophysiologie des hyalinen Knorpels. Deutsche Zeitschrift für Sportmedizin. 2003; 54 (6) 166-170
- 09 Rokosova B, Chvapil M. Relationship between the dose of ascorbic acid and its structural analogs in proline hydroxylation in various biological systems. Connective Tissue Research. 1974; 2 215-221
- 10 Schubotz R, Hausmann L. Behandlung degenerativer Gelenkerkrankungen mit N-Azetyl-hydroxyprolin. Therapiewoche. 1977; 27 4248-4252
- 11 Thall P F, Lachin J M. Analysis of recurrent events: Nonparametric methods for random interval count data. J Am Assoc. 1988; 83 339-347
- 12 Udenfried S. Formation of hydroxyproline in collagen. Science. 1966; 152 (3727) 1335-1340
- 13 Wei L J, Lachin J M. Two-sample asymptotically distribution-free tests for incomplete multivariate observations. J Am Stat Assoc. 1984; 79 653-661
Korrespondenzadresse
Dr. Dr. med. Winfried Miller
Facharzt für Allgemeinmedizin
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87435 Kempten/Allgäu