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DOI: 10.1055/s-0029-1216359
© Georg Thieme Verlag KG Stuttgart · New York
Low Serum Adiponectin Predicts 10-Year Risk of Type 2 Diabetes and HbA1c Independently of Obesity, Lipids, and Inflammation: Whitehall II Study
Publikationsverlauf
received 26.11.2008
accepted 02.03.2009
Publikationsdatum:
15. April 2009 (online)
Abstract
Our aim of the present work was to study the effect of serum adiponectin on incident diabetes and HbA1c values. We measured baseline serum adiponectin levels in a nested case-control selection (n=140) of the Whitehall II Cohort. Participants (mean [SD] age 50.9 [6.3] years) had no prevalent diabetes or CHD at baseline. Cases (n=55) had incident diabetes according to an oral glucose tolerance test during follow-up (mean: 11.5±3.0 years). Adiponectin levels were lower among cases (9.3 μg/ml, 3.2 [median; IQR] vs. 10.5; 3.6, p=0.01). The risk of incident diabetes decreased by 11% (p=0.03) for 1 μg/ml higher adiponectin levels. Higher adiponectin levels were associated with lower HbA1c at follow-up (p<0.05). Both associations were stable to adjustment for age, sex, body mass index, systolic blood pressure, and serum lipids, and for the case of HbA1c, also for C-reactive protein (all p<0.05). The observed robust, prospective associations support that adiponectin is an independent predictor of diabetes and the degree of glycaemic impairment.
Key words
adipokines - follow-up studies - haemoglobin A - glycosylated - C-reactive protein
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Correspondence
A. G. TabákMD
Department of Epidemiology and Public Health
University College London
1-19 Torrington Place
London WCE1 6BT
UK
Telefon: +44/20/7679 17 28
Fax: +44/20/7419 67 32
eMail: a.tabak@ucl.ac.uk