Synthesis 2009(14): 2447-2453  
DOI: 10.1055/s-0029-1216829
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Potassium [1-(tert-Butoxycarbonyl)-1H-indol-2-yl]trifluoroborate as an Efficient Building Block in Palladium-Catalyzed Suzuki-Miyaura Cross Couplings

Paméla Kassis, Valérie Bénéteau*, Jean-Yves Mérour, Sylvain Routier*
Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 6005, Rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France
Fax: +33(2)38417281; e-Mail: sylvain.routier@univ-orleans.fr;
Further Information

Publication History

Received 25 February 2009
Publication Date:
27 May 2009 (online)

Abstract

Potassium [1-(tert-butoxycarbonyl)-1H-indol-2-yl]tri­fluoroborate (1) was used in Suzuki-type coupling reactions. First, the best coupling conditions were assessed using bromobenzene as the electrophile. Then, 1 was successfully coupled with various aryl and hetaryl bromides. Finally, the reactivity of 1 towards coupling partners other than bromide derivatives was evaluated.