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Synthesis 2009(13): 2175-2178
DOI: 10.1055/s-0029-1216840
DOI: 10.1055/s-0029-1216840
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Practical Synthesis of 5-Substituted Tetrazoles under Microwave Irradiation
Weitere Informationen
Received
16 February 2009
Publikationsdatum:
27. Mai 2009 (online)
Publikationsverlauf
Publikationsdatum:
27. Mai 2009 (online)
Abstract
5-Substituted tetrazoles were prepared by treatment of nitriles with sodium azide and triethylammonium chloride in nitrobenzene in a microwave reactor. This practical method combines the advantages of previous procedures, including good-to-excellent yields, short reaction times, and easy isolation of the product. Moreover, sterically hindered tetrazoles, as well as those deactivated by electron-donating groups, can be prepared.
Key words
tetrazoles - microwave irradiation - sodium azide - heterocycles - nitriles
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