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Synthesis 2009(13): 2175-2178  
DOI: 10.1055/s-0029-1216840
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Practical Synthesis of 5-Substituted Tetrazoles under Microwave Irradiation

Jaroslav Roh*a, Tatjana V. Artamonovab, Kateřina Vávrováa, Grigorii I. Koldobskiib, Alexandr Hrabáleka
a Faculty of Pharmacy, Centre for New Antivirals and Antineoplastics, Charles University, Heyrovského 1203, 50005 Hradec Kralove, Czech Republic
Fax: +420(495)067166; e-Mail: jaroslav.roh@faf.cuni.cz;
b St. Petersburg State Institute of Technology, Moskovskii pr. 26, 190013 St. Petersburg, Russian Federation
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Publikationsverlauf

Received 16 February 2009
Publikationsdatum:
27. Mai 2009 (online)

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Abstract

5-Substituted tetrazoles were prepared by treatment of nitriles with sodium azide and triethylammonium chloride in nitrobenzene in a microwave reactor. This practical method combines the advantages of previous procedures, including good-to-excellent yields, short reaction times, and easy isolation of the product. Moreover, sterically hindered tetrazoles, as well as those deactivated by electron-donating groups, can be prepared.

Key words

tetrazoles - microwave irradiation - sodium azide - heterocycles - nitriles

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