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Synthesis 2009(21): 3677-3683  
DOI: 10.1055/s-0029-1217001
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Original and Efficient Synthesis of Substituted 3,4-Dihydronaphtho[2,3-g]quinoline-2,6,11(1H)-triones

Omar Khoumeri, Thierry Terme, Patrice Vanelle*
Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III - CNRS, UMR 6264, Laboratoire Chimie Provence, 27 Bd. J. Moulin, 13385 Marseille Cedex 05, France
Fax: +33(491)794677; e-Mail: patrice.vanelle@pharmacie.univ-mrs.fr;
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Publication History

Received 15 June 2009
Publication Date:
08 September 2009 (online)

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Abstract

We report an original and short synthesis of substituted 3,4-dihydronaphtho[2,3-g]quinoline-2,6,11(1H)-triones by using the tetrakis(dimethylamino)ethylene or malonate substitution strategies, followed by a one-pot reduction-cyclization reaction.

Key words

quinones - electron transfer - cyclization - malonate - naphthoquinolinetriones

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