Efficient Methods for the Synthesis of Thieno[3,2-b]thiophene and Thieno[3,2-b]furan Derivatives

Abstract

A novel approach to the synthesis of thieno[3,2-b]thiophenes and thieno[3,2-b]furans bearing various substituents from readily accessible starting materials has been developed. The methodology is based on C- and O-alkylation of ethyl 4-hydroxy-2-methylthiophene-3-carboxylate with α-halo ketones, followed by cyclization.

Key words

alkylation - cyclization - heterocycles - thienothio­phenes - thienofurans

References

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