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Synthesis 2009(23): 3957-3962
DOI: 10.1055/s-0029-1217042
DOI: 10.1055/s-0029-1217042
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Highly Efficient Method for C-5 Halogenation of Pyrimidine-Based Nucleosides in Ionic Liquids
Further Information
Received
14 April 2009
Publication Date:
12 October 2009 (online)
Publication History
Publication Date:
12 October 2009 (online)
Abstract
A novel, highly efficient, convenient, and benign methodology for C-5 halogenation of pyrimidine-based nucleosides has been developed using N-halosuccinimides as halogenating reagents without using any catalyst in ionic liquid medium. The ionic liquids were successfully recovered and reused for all the reactions.
Key words
ionic liquids - nucleosides - halogenation
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