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Synthesis 2010(1): 30-32
DOI: 10.1055/s-0029-1217055
DOI: 10.1055/s-0029-1217055
SHORTPAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Concise Regiospecific Synthesis of 5-Chloropyrido[4,3-d]pyrimidin-4(3H)-one
Further Information
Received
15 July 2009
Publication Date:
19 October 2009 (online)
Publication History
Publication Date:
19 October 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/201001/lookinside/thumbnails/10.1055-s-0029-1217055-1.jpg)
Abstract
A concise synthesis of 5-chloropyrido[4,3-d]pyrimidin-4(3H)-one was developed based on a unique regiospecific introduction of a tert-butoxycarbonyl group at the C-3 position of 4-amino-2-chloropyridine.
Key words
pyridopyrimidines - pyridines - rearrangement - regiospecificity - medicinal chemistry
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