Chemoenzymatic Synthesis of Substituted 1H-Inden-1-ones Using Lipases

Abstract

A practical and straightforward chemoenzymatic synthesis of novel acetoxy- and hydroxy-1H-inden-1-ones starting from commercial indan-1-ones is described. By using different lipases, the final step of the preparation can be performed with high conversion working under mild reaction conditions. The desired compounds, which present a great interest since they can be employed as target substrates in enzymatic activity detection assays, were obtained in good overall yields.

Key words

enzymes - elimination - hydrolyses - ketones - fluorogenic compounds

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