A practical and straightforward chemoenzymatic synthesis of novel
acetoxy- and hydroxy-1H-inden-1-ones
starting from commercial indan-1-ones is described. By using different
lipases, the final step of the preparation can be performed with
high conversion working under mild reaction conditions. The desired
compounds, which present a great interest since they can be employed as
target substrates in enzymatic activity detection assays, were obtained
in good overall yields.
enzymes - elimination - hydrolyses - ketones - fluorogenic compounds
