Stereoselective Synthesis and
Biological Studies of the C2 and C3 Epimer and the Enantiomer of
Pachastrissamine (Jaspine B)

G. Jayachitra; N. Sudhakar; Ravi Kumar Anchoori; B. Venkateswara Rao; Sayantani Roy; Rajkumar Banerjee

doi:10.1055/s-0029-1217096

PAPER

Stereoselective Synthesis and Biological Studies of the C2 and C3 Epimer and the Enantiomer of Pachastrissamine (Jaspine B)

G. Jayachitra^a, N. Sudhakar^a, Ravi Kumar Anchoori^a, B. Venkateswara Rao*^a, Sayantani Roy^b, Rajkumar Banerjee^b
^a Organic Division III, Indian Institute of Chemical Technology, Hyderabad 500007, India
Fax: +91(40)27193003; e-Mail: venky@iict.res.in;
^b Lipid Science and Technology, Indian Institute of Chemical Technology, Hyderabad 500007, India

Abstract

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Abstract

The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from d-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.

Key words

cytotoxicity - d-glucose - pachastrissamine - jaspine B - Mitsunobu inversion - Wittig olefination

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References

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