Simple and Convenient Method for the Synthesis of 2-Substituted Glutaconaldehyde Salts and 2-Substituted Glutaconaldehyde Derivatives

Abstract

Convenient and scalable syntheses of 2-substituted glutaconaldehyde salts were accomplished from the corresponding pyridinium salts. Glutaconaldehyde salts were additionally converted into aminopentadienal derivatives.

Key words

Zincke aldehydes - aminopentadienal derivatives - pyridinium salts - glutaconaldehyde

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14

The yield of a reaction between 4 and an amine could change from trace to quantitative.

17

5i is not sufficiently soluble in CDCl₃ to record a ^¹³C spectrum and decomposition was observed when other solvents were used.