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Synthesis 2010(1): 103-109
DOI: 10.1055/s-0029-1217105
DOI: 10.1055/s-0029-1217105
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Simple and Convenient Method for the Synthesis of 2-Substituted Glutaconaldehyde Salts and 2-Substituted Glutaconaldehyde Derivatives
Further Information
Received
30 July 2009
Publication Date:
06 November 2009 (online)
Publication History
Publication Date:
06 November 2009 (online)
Abstract
Convenient and scalable syntheses of 2-substituted glutaconaldehyde salts were accomplished from the corresponding pyridinium salts. Glutaconaldehyde salts were additionally converted into aminopentadienal derivatives.
Key words
Zincke aldehydes - aminopentadienal derivatives - pyridinium salts - glutaconaldehyde
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The yield of a reaction between 4 and an amine could change from trace to quantitative.
175i is not sufficiently soluble in CDCl3 to record a ¹³C spectrum and decomposition was observed when other solvents were used.