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Synthesis 2010(2): 249-254  
DOI: 10.1055/s-0029-1217108
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Expedient Three-Component Synthesis of Tertiary Benzylamines

Erwan Le Gall*, Alexandre Decompte, Thierry Martens, Michel Troupel
Électrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris-Est, UMR 7182 CNRS - Université Paris Est, 2-8 rue Henri Dunant, 94320 Thiais, France
Fax: +33(1)49781148; e-Mail: legall@glvt-cnrs.fr;
Further Information

Publication History

Received 9 July 2009
Publication Date:
06 November 2009 (online)

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Abstract

A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde is described. This procedure, which involves the in situ formation of arylzinc reagents, allows the straightforward synthesis of a range of functionalized tertiary benzylamines.

Key words

multicomponent reactions - amines - catalysis - zinc - organometallic­ reagents

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