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Synthesis 2010(2): 249-254
DOI: 10.1055/s-0029-1217108
DOI: 10.1055/s-0029-1217108
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkAn Expedient Three-Component Synthesis of Tertiary Benzylamines
Weitere Informationen
Received
9 July 2009
Publikationsdatum:
06. November 2009 (online)
Publikationsverlauf
Publikationsdatum:
06. November 2009 (online)

Abstract
A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde is described. This procedure, which involves the in situ formation of arylzinc reagents, allows the straightforward synthesis of a range of functionalized tertiary benzylamines.
Key words
multicomponent reactions - amines - catalysis - zinc - organometallic reagents
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