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Synthesis 2010(4): 714-717  
DOI: 10.1055/s-0029-1217110
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

A Practical Synthesis of 1-N-SEM-Protected 3-Iodo-7-methyl-2-piperidin-3-ylindole

James G. Phillips*a, Maria Jaworskaa, Willard Lewb
a Curragh Chemistries Inc., c/o Sherwin Williams Cradle, 7650 Hub Parkway, Valley View, OH 44125, USA
e-Mail: contractcurragh@yahoo.com ;
b Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA
Further Information

Publication History

Received 31 August 2009
Publication Date:
13 November 2009 (online)

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Abstract

A convenient procedure for the preparation of the 1-N-SEM-protected 3-iodo-7-methyl-2-piperidin-3-ylindole 3 is described. This scaffold provides access to unique and diverse 7-methyl-substituted indole libraries.

Key words

7-methylindoles - Fischer cyclization - 3-iodoindoles - 1,2,3,7-substituted indoles

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