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Synthesis 2010(3): 453-464
DOI: 10.1055/s-0029-1217116
DOI: 10.1055/s-0029-1217116
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient One-Pot Synthesis of Spirooxindole Derivatives by Ethylenediamine Diacetate Catalyzed Reactions in Water
Weitere Informationen
Received
2 September 2009
Publikationsdatum:
13. November 2009 (online)
Publikationsverlauf
Publikationsdatum:
13. November 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/201003/lookinside/thumbnails/10.1055-s-0029-1217116-1.jpg)
Abstract
A simple and efficient one-pot synthetic approach was used for the preparation of biologically interesting spirooxindole derivatives by means of three-component reactions of isatins, malononitrile, and 1,3-dicarbonyl compounds catalyzed by ethylenediamine diacetate (EDDA) in an aqueous medium. This method is of great value because of its environmentally benign character, high yield, and easy handling.
Key words
spiro compounds - indoles - catalysis - Brønsted acids - Brønsted bases - water
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