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Synthesis 2009(15): 2497-2500
DOI: 10.1055/s-0029-1217391
DOI: 10.1055/s-0029-1217391
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Ring-Opening/Recyclization Reactions of (Dimethylamino)propenoyl-Substituted Cyclopropanes: Facile Synthesis of Halogenated Pyridin-2(1H)-ones
Weitere Informationen
Received
25 February 2009
Publikationsdatum:
08. Juni 2009 (online)
Publikationsverlauf
Publikationsdatum:
08. Juni 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200915/lookinside/thumbnails/10.1055-s-0029-1217391-1.jpg)
Abstract
A facile and efficient synthesis of substituted pyridin-2(1H)-ones has been developed by the reaction of readily available 1-carbamoyl-1-[3-(dimethylamino)propenoyl]cyclopropanes with phosphoryl chloride or phosphorus tribromide in dichloromethane at room temperature.
Key words
cyclization - cyclopropanes - enaminones - pyridin-2(1H)-ones - ring opening
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