Synthesis of C13-C23 Fragment of Iriomoteolide-1a

Abstract

Highly efficient asymmetric conjugate addition of MeMgBr to α,β-unsaturated esters catalyzed by CuI/Tol-BINAP, Paterson aldol, organocatalytic aldol, and cross-metathesis reactions were applied in the synthesis of C13-C23 fragment of Iriomoteolide-1a.

Key words

asymmetric conjugate addition - organocatalytic aldol - cross-metathesis - Iriomoteolide-1a

References

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  The absolute configuration of 22 was determined based on this reference.

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Private communication with Professor Ian Paterson.