Synthesis of Bifunctional Hydroxamic Acids as Novel Ligands for the Hydrophilic Stabilization of Iron Oxide Nanoparticles

Abstract

A general method for synthesizing bifunctional hydroxamic acids containing carboxylic acid or amino functionalities is reported. Various products from simple alkyl to complex dendrimer-like structures are described. Such molecules have recently been used in ligand-exchange reactions for the hydrophilic stabilization of originally oleic acid protected iron oxide nanoparticles.

Key words

protecting groups - hydroxamic acids - hydrogenation - ethers - alkylations

References

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Hofmann, A.; Graf, C.; Semisch, A.; Hartwig, A.; Rühl, E. manuscript in preparation.