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Synthesis 2010(8): 1334-1338  
DOI: 10.1055/s-0029-1218672
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Straightforward Access to α-Methylamines through Cross-Metathesis

Florent Poulhèsa, Rémy Sylvaina, Patricia Perfettia, Michèle P. Bertrand*a, Gérard Gil*b, Stéphane Gastaldi*a
a Laboratoire de Chimie Moléculaire Organique, LCP UMR 6264, Boite 562, Université Paul Cézanne, Aix-Marseille III, Faculté des Sciences St Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France
e-Mail: stephane.gastaldi@univ-cezanne.fr;
b Laboratoire de Stéréochimie Dynamique et Chiralité, ISM2, UMR 6263, Université Paul Cézanne Aix-Marseille III, Faculté des Sciences St Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France
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Publikationsverlauf

Received 15 December 2009
Publikationsdatum:
05. Februar 2010 (online)

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Abstract

A two-step procedure involving cross-metathesis and reductive amination enables easy access to α-methylamines and α,α′-dimethyldiamines from a wide variety of terminal olefins.

Key words

amines - alkenes - metathesis - ruthenium - hydrogenation

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