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Synthesis 2010(10): 1625-1628  
DOI: 10.1055/s-0029-1218703
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Efficient New Method for the Synthesis of Polysubstituted Pyrroles [¹]

Biswanath Das*, Gandolla Chinna Reddy, Penagaluri Balasubramanyam, Boyapati Veeranjaneyulu
Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27193198; e-Mail: biswanathdas@yahoo.com;
Further Information

Publication History

Received 1 February 2010
Publication Date:
15 March 2010 (online)

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Abstract

The three-component reactions of phenacyl bromide or its derivatives, amine, and dialkyl acetylenedicarboxylate in the presence of iron(III) chloride as a catalyst at room temperature afforded polysubstituted pyrroles in high yields.

Key words

polysubstituted pyrroles - three-component reaction - iron(III) chloride

1

Part 283 in the series ‘Studies on Novel Synthetic Methodologies’.

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1

Part 283 in the series ‘Studies on Novel Synthetic Methodologies’.