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Synthesis 2010(10): 1625-1628
DOI: 10.1055/s-0029-1218703
DOI: 10.1055/s-0029-1218703
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
An Efficient New Method for the Synthesis of Polysubstituted Pyrroles [¹]
Further Information
Received
1 February 2010
Publication Date:
15 March 2010 (online)
Publication History
Publication Date:
15 March 2010 (online)
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Abstract
The three-component reactions of phenacyl bromide or its derivatives, amine, and dialkyl acetylenedicarboxylate in the presence of iron(III) chloride as a catalyst at room temperature afforded polysubstituted pyrroles in high yields.
Key words
polysubstituted pyrroles - three-component reaction - iron(III) chloride
Part 283 in the series ‘Studies on Novel Synthetic Methodologies’.
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References
Part 283 in the series ‘Studies on Novel Synthetic Methodologies’.