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Synthesis 2010(11): 1924-1928
DOI: 10.1055/s-0029-1218705
DOI: 10.1055/s-0029-1218705
PSP
© Georg Thieme Verlag
Stuttgart ˙ New YorkEconomic Large-Scale Synthesis of o- and m-Diphenylphosphinobenzoic Acids
Weitere Informationen
Received
17 February 2010
Publikationsdatum:
15. März 2010 (online)
Publikationsverlauf
Publikationsdatum:
15. März 2010 (online)

Abstract
An efficient and simple to perform large-scale synthesis of o- and m-diphenylphosphinobenzoic acids is presented. In a single step, both useful carboxylic acid-functionalized phosphines can be accessed starting from the same inexpensive bulk chemicals o-chlorobenzoic acid, triphenylphosphine, and sodium. In both cases the formation of the desired product is controlled by the ratio of the starting materials only. Additionally, X-ray crystallographic data are reported for both products.
Key words
phosphorus ligand - catalysis - aromatic carboxylic acid - directing group - Birch conditions
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Phosphorus Ligands in Asymmetric
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