Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000084.xml
Synthesis 2010(13): 2201-2206
DOI: 10.1055/s-0029-1218818
DOI: 10.1055/s-0029-1218818
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Chemical Probes for Labeling of the Bacterial Glucosaminidase NagZ via the Huisgen Cycloaddition
Further Information
Received
6 April 2010
Publication Date:
15 June 2010 (online)
Publication History
Publication Date:
15 June 2010 (online)
Abstract
Glycoside hydrolases represent a large class of enzymes that cleave carbohydrate motifs. Since some enzymes play crucial roles in bacterial resistance pathways, we here introduce the synthesis and application of small sugar-based probes to study the function of the glycoside hydrolase NagZ.
Key words
carbohydrates - cycloaddition - glycoside hydrolases
- 1
Henrissat B.Davies G. Curr. Opin. Struct. Biol. 1997, 7: 637 - 2
Zechel DL.Withers SG. Acc. Chem. Res. 2000, 33: 11 - 3
Adam GC.Sorensen EJ.Cravatt BF. Mol. Cell. Proteomics 2002, 1: 781 - 4
Hekmat O.Kim YW.Williams SJ.He S.Withers SG. J. Biol. Chem. 2005, 280: 35126 - 5
Hinou H.Kurogochi M.Shimizu H.Nishimura S. Biochemistry 2005, 44: 11669 - 6
Kurogochi M.Nishimura S.Lee YC. J. Biol. Chem. 2004, 279: 44704 - 7
Romaniouk AV.Silva A.Feng J.Vijay IK. Glycobiology 2004, 14: 301 - 8
Tsai CS.Li YK.Lo LC. Org. Lett. 2002, 4: 3607 - 9
Vocadlo DJ.Bertozzi CR. Angew. Chem. Int. Ed. 2004, 43: 5338 - 10
Williams SJ.Hekmat O.Withers SG. ChemBioChem 2006, 7: 116 - 11
Lu CP.Ren CT.Lai YN.Wu SH.Wang WM.Chen JY.Lo LC. Angew. Chem. Int. Ed. 2005, 44: 6888 - 12
van Scherpenzeel M.van den Berg RJ.Donker-Koopman WE.Liskamp RM.Aerts JM.Overkleeft HS.Pieters RJ. Bioorg. Med. Chem. 2010, 18: 267 - 13
Rostovtsev VV.Green LG.Fokin VV.Sharpless KB. Angew. Chem. Int. Ed. 2002, 41: 2596 - 14
Tornoe CW.Christensen C.Meldal M. J. Org. Chem. 2002, 67: 3057 - 15
Osborn H. M. I. Carbohydrates Academic Press; London: 2003.