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Synthesis 2010(15): 2571-2576
DOI: 10.1055/s-0029-1218824
DOI: 10.1055/s-0029-1218824
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Three-Component One-Pot Synthesis of 3-(2-Furanyl)indoles from Acetylenedicarboxylate, Isocyanide, and 3-Formylindole
Weitere Informationen
Received
29 March 2010
Publikationsdatum:
18. Juni 2010 (online)
Publikationsverlauf
Publikationsdatum:
18. Juni 2010 (online)
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Abstract
The zwitterions derived from isocyanide and dimethyl acetylenedicarboxylate undergo smooth condensation with 3-formylindoles in benzene at room temperature to give the corresponding 3-(2-furanyl)indoles in good yields. This method provides a simple and convenient route to produce a wide range of 3-heteroarylindoles in a one-pot operation.
Key words
3-formylindoles - isocyanides - DMAD - zwitterions - 3-furanylindoles
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