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Synthesis 2010(15): 2547-2552
DOI: 10.1055/s-0029-1218826
DOI: 10.1055/s-0029-1218826
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Concise Synthesis of Natural Benzofuran Neolignans and Analogues
Further Information
Received
23 March 2010
Publication Date:
17 June 2010 (online)
Publication History
Publication Date:
17 June 2010 (online)
Abstract
The first total synthesis of four naturally occurring benzofuran neolignans and two analogues was achieved in four steps in 44-51% overall yield. Key steps involved a two-step construction of benzofuran nucleus and a Suzuki coupling. This synthesis has been proven straightforward and efficient, and more related analogues can be prepared for structure-activity relationship explorations.
Key words
benzofuran - neolignan - McMurry reaction - Suzuki coupling
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