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Synthesis 2010(6): 967-970
DOI: 10.1055/s-0029-1219219
DOI: 10.1055/s-0029-1219219
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Noncatalytic Electrophilic Alkylation of 1H-Indole with 2-Trifluoroacetyl-1,3-heterazoles
Weitere Informationen
Received
27 October 2009
Publikationsdatum:
04. Januar 2010 (online)
Publikationsverlauf
Publikationsdatum:
04. Januar 2010 (online)
Abstract
A set of highly electrophilic 2-trifluoroacetyl-1,3-heterazoles demonstrated excellent activity in the C-hydroxyalkylation of 1H-indole. The reaction conditions and yields of the corresponding trifluoromethyl-substituted alcohols depend strongly on the electron-withdrawing nature of the 1,3-heterazole unit.
Key words
1,3-heterazoles - alkylations - trifluoromethyl alcohols - indoles - electrophilic additions
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