Role of Platelet Electron Microscopy in the Diagnosis of Platelet Disorders

Sylvain Clauser; Elisabeth Cramer-Bordé

doi:10.1055/s-0029-1220329

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2009; 35(2): 213-223
DOI: 10.1055/s-0029-1220329

Role of Platelet Electron Microscopy in the Diagnosis of Platelet Disorders

Sylvain Clauser¹ , Elisabeth Cramer-Bordé²

¹Service d'Hématologie-Immunologie, Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, Boulogne, Université de Versailles, Saint Quentin en Yvelines, France
²INSERM U567, Département d'Hématologie, Institut Cochin, Maternité Port Royal, Paris, France

Abstract

ABSTRACT

The electron microscope has proved to be a useful tool to study and understand the biology of platelets and to classify many platelet disorders. After a technical overview, this article reviews syndromes originating from platelet organelle, cytoskeleton, and membrane defects for which electron microscopy plays a role in the diagnostic process, such as gray platelet syndrome, Paris-Trousseau syndrome, storage pool diseases, MYH9-related thrombocytopenias, or Wiskott-Aldrich syndrome. Particular focus is given to the ultrastructural aspect of platelets in these disorders.

KEYWORDS

Platelet - electron - microscopy - diagnosis

Full Text

References

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Pr. Elisabeth Cramer-Bordé

Service d'Hématologie-Immunologie, Hôpital Ambroise Paré

9, avenue Charles de Gaulle, 92104 Boulogne-Billancourt, France

Email: elisabeth.borde@apr.aphp.fr